Antibodies, viruses and vaccines

By D. Burton. Nature reviews. Immunology, 2002

658 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/0c4fadfbd99f7b5fd3eacd541cc837630403fde5

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Citations in the corpus

New Vaccine Design and Delivery Technologies (2019, background): “Many recent advances in vaccine development have been driven by structures of antibodies and their targets, often in complex, which inform approaches aimed at eliciting desired responses using designed immunogens [16] [17] [18] [19] [20] (Figure 1 ).”
Comprehensive Cross-Clade Neutralization Analysis of a Panel of Anti-Human Immunodeficiency Virus Type 1 Monoclonal Antibodies (2004, background): “Therefore, even the broadest of the NAbs are unable to neutralize all isolates in a PBMC assay.”
From Vaccines to Memory and Back (2010, positive): “Interrogation of Memory B Cells and Isolation of Monoclonal Antibodies The concept that cross-reactive protective antigens could be identified by studying the antibody response was initially proposed in the context of HIV vaccine design (Burton, 2002).”
Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization (2018, background): “A different approach based on isolating functional antibodies to the pathogen by studying their interaction with their targets and then designing vaccine candidates has been described (Burton, 2002, 2017; McLellan et al., 2013; Rappuoli and De Gregorio, 2016; Walker et al., 2009).”
Virus entry: molecular mechanisms and biomedical applications (2004, background): “Rhabdoviridae ssRNA Enveloped Rabies virus Endocytosis, acetylcholine Rabies (11-15) (45-100) receptor, neural cell adhesion molecule”
Adenoviruses as vaccine vectors (2004, neutral): “Initial attempts to develop vaccines that generate broadly cross-reactive neutralizing antibodies to the human immunodeficiency virus (HIV) -1 failed [84] and most vaccines currently under development focus on stimulating T cells, most notably CD8 T cells, against conserved sequences of HIV-1 [85].”
Structural definition of a conserved neutralization epitope on HIV-1 gp120 (2007, neutral): “Two strategies have been proposed to surmount these barriers: examination of known broadly neutralizing antibodies (2F5, 2G12, 4E10 and b12) to identify susceptible targets of neutralization 12 , and analysis of functional constraints to identify potential sites of vulnerability 13 .”