Design of biodegradable particles for protein delivery.

By A. Vila, Alejandro Sanchez, M. Tobío, P. Calvo, M. J. Alonso. Journal of Controlled Release, 2002

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Nanocarriers’ entry into the cell: relevance to drug delivery (2009, background): “Nanoparticles coated with either chitosan or hyaluroic acid have led to many examples of increased in vivo association to mucosae in the gastrointestinal tract [115], in the nasal mucosa [116] and in the cornea [117].”
Nanoparticles - A Review (2007, methodology): “Various methods which can be used to study the in vitro release of the drug are: (1) side-by-side diffusion cells with artificial or biological membranes; (2) dialysis bag diffusion technique; (3) reverse dialysis bag technique; (4) agitation followed by ultracentrifugation/centrifugation; (5) Ultra”
Nanotechnology: Intelligent Design to Treat Complex Disease (2006, background): “The coencapsulation of Fe3O4 in PLA nanosphere (321) or the coating of the nanodevice with hydrophilic polymers like chitosan or poly(ethylenoxide) (309,324) can improve the protection of the encapsulated peptide against degradation.”
Oral Drug Delivery with Polymeric Nanoparticles: The Gastrointestinal Mucus Barriers (2011, background): “Coating PLGA nanoparticles with chitosan improved the absorption of tetanus toxoid [55] and salmon calcitonin [56].”
Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines (2011, neutral): “PEG is also believed to facilitate mucoadhesion and consequent transport through the Peyer’s patches of the GALT (gut associated lymphoid tissue) [37].”