Nanoparticles - A Review
By V. Mohanraj, Y. Chen. 2007
1,751 citations recorded by the source corpus.
For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes.
Subfields: Biomaterials, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/dd9a8bf11166140cf41a8043ed0afbfa2be0c8cd
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In Biomaterials
In Pharmaceutical Science
Citations in the corpus
- Biological Synthesis of Metallic Nanoparticles by Bacteria, Fungi andPlants (2014, background): “Nanoparticles are defined as particulate dispersions of solid particles with at least one dimension at a size range of 10-1000 nm [2,6].”
- Double Emulsions: Emerging Delivery System for Plant Bioactives (2015, background): “Particle size ranging from 10 to 1,000 nm is considered appropriate for the target delivery of encapsulated material at a controlled and sustained rate (Mohanraj and Chen 2006).”
- Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines (2011, positive): “Since most biologically active macromolecules and agents such as viruses, membranes and protein complexes are natural nanostructures [2], it is assumed that nano-sized structures will be capable of enhanced interaction with cell membrane and proteins.”
- Biological Synthesis of Copper Nanoparticles and its impact-a Review (2014, background): “Nanoparticles (Nps) are solid particles with all three external dimension at the nano scale [3-10] that can drastically modify physico-chemical properties compared to the bulk material.”
- Use of iron oxide nanomaterials in wastewater treatment: a review. (2012, background): “Since the practical application depends on the type of modified medium, it would be critical to functionalize with various mediums (Mohanraj and Chen, 2007).”
- Antibacterial effects of chitosan–tripolyphosphate nanoparticles: impact of particle size molecular weight (2014, background): “All the nanoparticles prepared in this study were considered stable, and this was attributed to the high surface charge values ([30 mV), which prevented nanoparticles aggregation (Fan et al. 2012; Mohanraj and Chen 2006).”