Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

By A. Kreitzer, R. Malenka. Nature, 2007

735 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0bb24098b1e8148613213cc37ef8c0fe37b5ca8d

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In Cellular and Molecular Neuroscience

In Neurology

In Pharmacology

Citations in the corpus

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease (2008, background): “Movement disorders, especially Parkinson's disease, have been shown to be regulated by synaptic endocannabinoid signaling in the dorsal striatu”
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, methodology): “Moreover, similar to LTP, evidence is accumulating that LTD mechanisms may contribute to a large number of brain phenomena including experiencedependent development, learning and memory, addiction, and neurological disorders such as Alzheimer’s disease and Parkinson’s disease (Malenka and Bear, 2004”
Neuronal Reward and Decision Signals: From Theories to Data. (2015, background): “The released dopamine influences the plasticity between conjointly active presynaptic and postsynaptic neurons in a three factor Hebbian learning scheme (FIGURE 17, B AND C) involving striatum, frontal cortex, and other structures in which appropriate dopamine dependent plasticity is found (82, 194,”
Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol (2008, result): “…a dramatic segregation between the two populations of MSNs is in agreement with recent electrophysiological findings, which revealed that striatopallidal MSNs display several forms of plasticity that are absent in striatonigral MSNs (Day et al., 2006; Kreitzer and Malenka, 2007; Shen et al., 2007).”
Modulation of striatal projection systems by dopamine (2011, positive): “Studies have consistently found that in indirect pathway SPNs, D2 receptor activation is necessary (Wang et al., 2006; Kreitzer and Malenka, 2007; Shen et al., 2008).”
Synaptic plasticity and addiction (2007, background): “Such mice have already facilitated our understanding of the cell type-specific synaptic modifications that occur in the dorsal striatum following dopamine depletio”
Dopaminergic modulation of synaptic transmission in cortex and striatum (2012, background): “synaptic contacts onto these cells (Day et al., 2006; Gertler et al., 2008; Kreitzer and Malenka, 2007).”
Dendritic excitability and synaptic plasticity. (2008, positive): “In fact, there is also strong evidence supporting the need for cannabinoid signaling in several forms of long-term plasticity in hippocampus, neocortex, cerebellum, nucleus accumbens, and striatum (128, 191, 241, 391, 634, 658, 711, 712, 716), suggesting that endocannabinoids play”