A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

By B. Bruneau, G. Nemer, J. Schmitt, F. Charron, L. Robitaille, Sophie J C Caron, D. Conner, M. Gessler, M. Nemer, Christine E. Seidman and 1 more. Cell, 2001

1,102 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/0b9060c5b5e880c8802126c8fa27c5fde0e35f68

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Bruneau
2. A. Moorman
3. Deepak Srivastava

In Molecular Biology

1. B. Bruneau
2. V. Vedantham
3. A. Moorman
4. Deepak Srivastava

Citations in the corpus

• Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “Indeed, mice lacking the nuclear receptor CoupTFII lack atrial myocytes (Pereira et al., 1999), as do mice lacking Tbx5 (Bruneau et al., 2001).”
• Plasma membrane channels formed by connexins: their regulation and functions. (2003, background): “Transcription of Cx40 is transactivated by Tbx5 (T-box transcription factor 5) and the homeodomain transcription factor Nkx2–5 (62).”
• Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors (2010, background): “They interact with one another, coactivate cardiac gene expression (e.g., Nppa, Gja5 [Cx40], and Myh6), and promote cardiomyocyte differentiation (Bruneau et al., 2001; Garg et al., 2003; Ghosh et al., 2009; Lin et al., 1997).”
• Cardiac chamber formation: development, genes, and evolution. (2003, background): “Among the factors that interact with the Anf promoter are Gata family members, Nkx2–5, Mef2C, Tbx5, Tbx2, Srf, and Myocardin (36, 77, 78, 118, 124, 125, 175, 213, 279, 322).”
• The developmental genetics of congenital heart disease (2008, methodology): “The importance of transcription-factor dosage was confirmed by using mouse model”
• The Family of Connexin Genes (2009, background): “Tbx5 also plays a crucial role in regulating Gja5 expression, since levels of mRNA for Cx40 are markedly reduced in heterozygous Tbx5KOmice, a murine model for the HoltOram syndrome [49].”
• Building the mammalian heart from two sources of myocardial cells (2005, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=21388"> Tbx5 (T-box 5) mutant mic”