Signals for sorting of transmembrane proteins to endosomes and lysosomes.

By J. Bonifacino, L. Traub. Annual Review of Biochemistry, 2003

2,177 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0b5ba5f0af6c33fec1b362ead4cfe68e04273856

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

Citations in the corpus

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “Many LMPs contain di-leucine or tyrosine-based sorting motif”
Accessory proteins of SARS-CoV and other coronaviruses (2014, background): “The YxxU motif plays a role in internalization of proteins into various intracellular components, including proteins from the plasma membrane into the endosomes (Bonifacino and Traub, 2003; Trowbridge et al., 1993).”
Coronavirus Structural Proteins and Virus Assembly (2008, background): “This type of sequence binds the AP2 adaptor complex that, in turn, binds clathrin to induce endocytosis (8).”
Inwardly rectifying potassium channels: their structure, function, and physiological roles. (2010, background): “2 (position 13 and 14) and accelerated by dephosphorylation of Ser near the motif (position 9) (90), implying that phosphorylation status of Ser modulates functionality of the V-L motif similar to the case of diLeu-mediated internalization of other proteins (57).”
Molecular motors and mechanisms of directional transport in neurons (2005, background): “The cytoplasmic side of M6PR binds to the AP1 (ADAPTOR PROTEIN 1) ADAPTOR COMPLEX and is transported by clathrin-coated vesicles, primarily to endosomes but also to the cell surfac”
Nanomedicine in cancer therapy (2023, background): “Specifically, YXXØ and [DE]XXXL[LI] signals can be recognized by the adaptor protein complexes, while DXXLL by adaptors GGAs, and NPXY signals by other recognizing proteins.(436) Fecondo et al.”
The γ/σ1 and α/σ2 Hemicomplexes of Clathrin Adaptors AP-1 and AP-2 Harbor the Dileucine Recognition Site (2007, background): “Aside from a few exceptions, the dileucine-based motifs reported to date have either a glutamate or aspartate at the 4 position (Bonifacino and Traub, 2003).”
Clathrin-mediated endocytosis in AP-2–depleted cells (2003, background): “Th e Jo ur na l o f C el l B io lo gy The Rockefeller University Press, 0021-9525/2003/09/909/10 $8.00 The Journal of Cell Biology, Volume 162, Number 5, September 1, 2003 909–918 http://www.jcb.org/cgi/doi/10.1083/jcb.200305145 JCB Article 909”
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes (2006, background): “Interestingly, several well-characterized motifs (tyrosine and di-leucine motifs) (Bonifacino and Traub, 2003) are present within the cytosolic N- and C-terminal domains and loops, which may bind to clathrin-coat adaptors, including AP-1 and AP-3 (Robinson and Bonifacino, 2001), and other adaptors,…”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “The Gly-TyrGlu-Val-Met (GYEVM) sequence targets tetraspanin CD63 to the late endosomal–lysosomal compartment, while the motif YXXØ (Tyr-Xaa-Xaa-Ø, where Ø represents of an amino acid with a bulky hydrophobic side chain) is a sorting signal for clathrin-coated vesicles (27, 28).”
Sorting of lysosomal proteins. (2009, background): “that make them functional for lysosomal targeting [47] (Table 1).”
The Receptor for the Fungal Elicitor Ethylene-Inducing Xylanase Is a Member of a Resistance-Like Gene Family in Tomato (2004, background): “Bars ¼ 10 mm. domains possess a Tyr YXXø signal sequence, where ø is an amino acid with a hydrophobic side chain, which stimulates receptor-mediated endocytosis and degradation of mammalian cell-surface receptors (Letourneur and Klausner, 1992; Bonifacino and Traub, 2003).”
Phosphatidylinositol-4-Kinase Type II α Is a Component of Adaptor Protein-3-derived Vesicles (2005, background): “We detected the AP-3 cargo proteins LAMP 1, 2, and TI-VAMP/VAMP7 (Bonifacino and Traub, 2003; Martinez-Arca et al., 2003), an AP3–interacting protein that regulates lysosome content (ATM) (Lim et al.”
The tetraspanin web modulates immune-signalling complexes (2005, background): “This tyrosine-based motif is involved in cellular sorting, including internalization, and lysosomal and basolateral targeting, although the mechanism has yet to be fully explore”