Pharmaceutical Particle Engineering via Spray Drying
By Reinhard Vehring. Pharmaceutical Research, 2007
1,634 citations recorded by the source corpus.
This review covers recent developments in the area of particle engineering via spray drying. The last decade has seen a shift from empirical formulation efforts to an engineering approach based on a better understanding of particle formation in the spray drying process. Microparticles with nanoscale substructures can now be designed and their functionality has contributed significantly to stability and efficacy of the particulate dosage form. The review provides concepts and a theoretical framework for particle design calculations. It reviews experimental research into parameters that influence particle formation. A classification based on dimensionless numbers is presented that can be used to estimate how excipient properties in combination with process parameters influence the morphology of the engineered particles. A wide range of pharmaceutical application examples—low density particles, composite particles, microencapsulation, and glass stabilization—is discussed, with specific emphasis on the underlying particle formation mechanisms and design concepts.
Subfields: Food Science, Pharmaceutical Science, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/0b4b25e89f329dafcec5fddfce9231506e590633
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In Food Science
Citations in the corpus
- Surface modification of spray dried food and emulsion powders with surface-active proteins: a review. (2009, background): “Elversson and Millqvist Fureby (2005) and Vehring(2008) investigated to what extent an aqueous two phase systems (ATPS) could encapsulate and protect the secondary structure of a protein during spray drying.”
- Strategies to Address Low Drug Solubility in Discovery and Development (2013, neutral): “This has conventionally been achieved using spray-drying (Vehring, 2008) but until recently has been limited to the production of micron-sized particles.”