Fluoxetine targets early progenitor cells in the adult brain.

By J. Encinas, A. Vaahtokari, G. Enikolopov. Proceedings of the National Academy of Sciences of the United States of America, 2006

642 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/0b2fcee5f07f3bbcb035e959b53bf65344cb0d6d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Guo-li Ming
4. R. Hen
5. E. Gould
6. R. Duman
7. B. Leuner
8. Arturo Alvarez-Buylla

In Developmental Neuroscience

1. Hongjun Song
2. Fred H. Gage
3. Guo-li Ming
4. R. Hen
5. E. Gould
6. B. Leuner
7. Arturo Alvarez-Buylla
8. R. Duman

Citations in the corpus

• Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “Interestingly, the creation of P ⁄ E-TcTex-1:GFP reporter mouse lines demonstrated that one group of adult mice with GFP predominantly labeled the neural stem Type-1 (GFAP+ ⁄ Sox2+ ⁄ Nestin+) cells or Type B cells in the SGZ and SVZ, respectively, whereas the other group of mice had GFP predominantl”
• Mechanisms and functional implications of adult neurogenesis. (2008, neutral): “chronic fluoxetine administration increases the proliferation of the type 2 hippocampal progenitors in mice (Encinas et al., 2006).”
• Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus (2011, methodology): “, fluoxetine, exercise, and deep brain stimulation (Encinas et al., 2011; Encinas et al., 2006; Hodge et al., 2008) act downstream of stem cells, at the level of ANPs and NBs, leaving the pool of stem cells unaffected.”
• Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “…primary precursors that divide to generate intermediate amplifying GFAPK/nestinC cells which in turn generate GFAPK/nestinK/DcxC cells that mature into differentiated granule neurons (Seri et al. 2001, 2004; Kronenberg et al. 2003; Kempermann et al. 2004; Steiner et al. 2004; Encinas et al. 2006).”
• Single-cell RNA-seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis (2015, methodology): “…of adult neurogenesis in vivo, we Cell S used a transgenic mouse line that expresses nucleus-localized CFP under the Nestin regulatory elements (Nes-CFPnuc) (Encinas et al., 2006), in which CFP proteins carry over from adult qNSCs to their immediate progeny (collectively named NPCs; Figure S1A).”
• Neurogenesis and Exercise: Past and Future Directions (2008, background): “In this context it is of interest that serotonergic agonists, including antidepressants such as fluoxetine (Malberg et al. 2000; Encinas et al. 2006), can enhance cell genesis, whereas administration of the serotonin 5-HT (1A) receptor antagonists, decreases cell proliferation in the DG (Radley and ”
• Experience dictates stem cell fate in the adult hippocampus. (2011, neutral): “Adult NSCs are currently thought to be a slowly dividing, relatively quiescent reservoir (Encinas et al., 2006), although this notion is beginning to be challenged (Lugert et al., 2010).”
• A Role for Hilar Cells in Pattern Separation in the Dentate Gyrus: A Computational Approach (2009, background): “This study suggests a role of postnatal neurogenesis , because 5-HT1A receptors mediate the well-known facilitation of neurogenesis by serotonin (Brezun and Daszuta, 1999; Radley and Jacobs, 2002; Encinas et al., 2006).”
• Type‐2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis (2006, background): “…developmental model of adult hippocampal neurogenesis (Kempermann et al., 2004): Encinas and colleagues, for example, collapsed what is type-2 and type-3 cells in our scheme into just one intermediate progenitor cell, which would be subject to the regulation of proliferation (Encinas et al., 2006).”
• Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis (2010, methodology): “…examples of the different types of contacts between microglia and NPCs, visualized in nestin-CFPNuc mice, in which the cyan fluorescent protein is expressed under the control of the nestin promoter and regulatory elements and is directed by a nuclear localization signal (Encinas et al., 2006).”
• Development of neural stem cell in the adult brain. (2008, background): “In particular, studies based on BrdU labeling and immunohistochemical markers have provided a detailed description of a series of intermediate developmental stages during hippocampal neurogenesis in vivo [15,16](Figure 2).”
• Benzodiazepines And The Potential Trophic Effect Of Antidepressants On Dentate Gyrus Cells In Mood Disorders (2014, positive): “, 2009, 2012), which suggest that antidepressants increase amplifying or type 2 NPCs (Encinas et al., 2006).”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “A recent study identified six distinct subclasses of neuronal precursor cells in the dentate gyrus and found that fluoxetine increases neurogenesis by augmenting proliferation of amplifying neural progenitor cells in the dentate gyrus (Encinas et al., 2006).”
• Structural Plasticity and Hippocampal Function (2010, background): “These lines allow for selective identification of cells at discrete developmental stages including neural stem cells, progenitor cells, and postmitotic, immature neurons (Couillard-Despres et al. 2006, Encinas et al. 2006, Overstreet et al. 2004, Yamaguchi et al. 2000).”
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment (2008, background): “Studies in rodents have shown that upon exposure to chronic ADs or exercise, neural progenitor cells (NPCs) in the subgranular zone (SGZ) of the DG undergo enhanced proliferation, which drives the increase in neurogenesis (Encinas et al., 2006).”
• Sox1 marks an activated neural stem/progenitor cell in the hippocampus (2012, background): “Although it is possible that the marked late progenitors/neuroblasts after the 12-week chase were somehow delayed in their differentiation rather than arising anew from traced radial astrocytes, this interpretation seems unlikely considering that the chase is three times longer than the reported 4we”