Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

By N. Iwakoshi, Ann-Hwee Lee, P. Vallabhajosyula, K. Otipoby, K. Rajewsky, Laurie H. Glimcher. Nature Immunology, 2003

912 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0aa572b6b3ea42e5ee8ad3b48d943ae1e9c7d531

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Citations in the corpus

Regulation of plasma-cell development (2005, background): “Increased IgH expression is required to activate IRE1α-dependent processing of Xbp1 mRN”
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, positive): “Antigenic stimulation of mature B lymphocytes activates the UPR, and signaling through IRE1-mediated XBP1 mRNA splicing is required to drive B-lymphocyte differentiation into plasma cells (13, 56, 112, 165).”
The endoplasmic reticulum stress response in immunity and autoimmunity (2008, background): “A role for the UPR in the immune system was first recognized in B-cell lymphopoiesis, when our laboratory showed that XBP1 was crucial for the development of terminally differentiated immunoglobulin-secreting plasma cell”
The unfolded protein response: controlling cell fate decisions under ER stress and beyond (2012, background): “In fact, XBP1 deficiency completely ablates immunoglobulin secretion, leading to the speculation that the high demand of immunoglobulin synthesis generates a basal stress condition that engages the UP”
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets (2007, background): “Both XBP-1s transcript and protein are expressed at high levels in multiple myeloma cells versus normal plasma cell”
Systems Biology of Seasonal Influenza Vaccination in Humans (2011, background): “The genes revealed by our study may offer new opportunities to study the complex mechanisms involved in the unfolded protein response and its link to ASC differentiation 18 .”
The role of the unfolded protein response in tumour development: friend or foe? (2004, neutral): “, the differentiation of immunoglobulin-secreting plasma cell”
The endoplasmic reticulum and the unfolded protein response. (2007, background): “Antigenic stimulation of mature B lymphocytes activates the UPR and signaling through IRE1-mediated XBP1 mRNA splicing is required to drive B lymphocyte differentiation into plasma cells [29,36-38].”
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response (2003, background): “It has been shown by others that ATF6 is involved in the induction of a subset of UPR target genes (61, 64, 65, 68) and that ATF6 (1-373) was sufficient for the induction of several UPR target genes, including BiP and CHOP (33).”
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer (2017, positive): “IL-4 had been demonstrated to control Xbp1 expression in B cells, and this process was required for optimal IL-6 synthesis by these lymphoid cells (Iwakoshi et al., 2003).”