Systems Biology of Seasonal Influenza Vaccination in Humans
By H. Nakaya, J. Wrammert, Eva K. Lee, L. Racioppi, Stephanie Marie-Kunze, W. Nicholas Haining, A. Means, S. Kasturi, Nooruddin Khan, Gui-Mei Li and 10 more. Nature Immunology, 2011
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Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines.
Subfields: Epidemiology, Immunology
View Paper: https://www.semanticscholar.org/paper/6db288ca0626197067e4fd16d8715023d36103b0
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Citations in the corpus
- Information Constraints on Auto-Encoding Variational Bayes (2018, background): “Our ground truth for the hypothesis testing, from microarray studies, is a set of genes that are differentially expressed between human B cells and dendritic cells (n=10 in each group [42]).”
- Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models (2019, neutral): “To evaluate performance on the real data, we defined genes as differentially expressed if the adjusted p-value in the reference bulk data (provided by (G € org € un et al , 2005; Nakaya et al , 2011)) was under 5%.”
- Immunosenescence: molecular mechanisms and diseases (2023, background): “Pulendran and colleagues conducted a series of clinical studies over three years to evaluate the responses to influenza vaccination in adults.(224) According to previous studies, later antibody titers correlate with early molecular signatures and can be accurately predicted.”
- Bayesian Inference for a Generative Model of Transcriptome Profiles from Single-cell RNA Sequencing (2018, background): “9) that are differentially expressed between human B cells and dendritic cells (microarrays, n=10 in each group [45]) and between CD4+ and CD8+ T cells (microarrays, n=12 in each group [46]).”