XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
By Ann-Hwee Lee, N. Iwakoshi, Laurie H. Glimcher. Molecular and Cellular Biology, 2003
2,137 citations recorded by the source corpus.
Subfields: Cell Biology, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/8af7b97d7cbca6c43043aa3068c8ce8037ad8c9e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Epidemiology
In Molecular Biology
Citations in the corpus
- The Unfolded Protein Response and Cell Fate Control. (2017, positive): “In cellular models of ER stress, XBP1s controls the expression of genes encoding factors that modulate protein folding, secretion, ERAD, protein translocation into the ER, and lipid synthesis (Acosta-Alvear et al., 2007; Lee et al., 2003).”
- Cellular response to endoplasmic reticulum stress: a matter of life or death (2006, methodology): “transcript, resulting in the replacement of the C-terminal domain of the protein and the translational activation of the mRNA, analogous to the splicing of HAC1 mRNA.(62,63,65)”
- Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes (2007, background): “Ddit3 mRNA levels were also increased in a step-wise fashion with time (p<0.002). mRNA levels of Dnajc3, another ER stress protein induced predominately downstream of ATF6 and XBP1 [28, 29], were unchanged at 4 h, but increased at 24 and 48 h, displaying a significant time-dependent effect (p<0.001)”
- Mediators of endoplasmic reticulum stress‐induced apoptosis (2006, background): “The generated frameshift splice variant (sXBP1) encodes a stable, active transcription factor (Yoshida et al, 2001). sXBP1 has diverse targets, including ER chaperones and the HSP40 family member P58IPK (Lee et al, 2003; Fig 1).”
- Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation (2009, background): “P5 is upregulated by XBP-1 as part of the unfolded protein response (179), suggesting a physiological role in protein folding.”
- A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response (2016, result): “As expected from previous work (Acosta-Alvear et al., 2007; Han et al., 2013; Lee et al., 2003; Shoulders et al., 2013), epistasis analysis using combinatorial depletions of PERK, ATF6, and IRE1α revealed both distinct and overlapping programs of gene expression.”
- Cardiotoxicity of the cancer therapeutic agent imatinib mesylate (2006, background): “XBP-1s then induces transcription of one or more proteins involved in ER-mediated protein degradatio”
- Endoplasmic reticulum stress: molecular mechanism and therapeutic targets (2023, background): “The miR29b component in the exosome is proved to affect autophagy and downregulate molecules involved in ER stress, including CHOP, ATF6, eIF2 α , and XBP1.”