AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

By S. Satoh, Y. Daigo, Yoichi Furukawa, Tatsushi Kato, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M. Fujita, T. Tokino and 6 more. Nature Genetics, 2000

1,002 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/09d18ed492960a3353826e84e56acdc16cc781a1

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Citations in the corpus

The β-catenin destruction complex. (2013, background): “Mutations in destruction complex components associated with various cancers result in inappropriate stabilization of b-catenin and Wnt target gene expression in the absence of a Wnt stimulus (Dominguez et al. 1995; Jiang and Struhl 1998; Marikawa and Elinson 1998; Peters et al. 1999; Liu et al. 2000”
Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway (2002, background): “The role of Axin in this signaling pathway predicts that it could function as a tumor suppressor gene, and indeed, mutations in human AXIN have been found to be associated with hepatocellular carcinoma (37).”
Molecular pathogenesis of human hepatocellular carcinoma (2002, background): “Heterogeneity of genomic changes in HCC Although nearly all HCCs contain multiple genes and loci with structural alterations, alterations in individual genes ( Table 1”
Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Axin1 mutations were first noted in hepatocellular carcinomas (Satoh et al., 2000).”
Wnt signaling in cancer. (2012, background): “Similarly, ectopic expression of Axin1, an additional tumor suppressor in the Wnt pathway, promoted apoptosis in colorectal and PGE2 LR P 5/ 6 E G F R Wnt fzd EP2 PKM2 src src PKM2 PKM2 P P PMGsα Gsα β-cat β-cat β-cat β-cat Cyclin D1 TCF ON HDAC3 β-cat GSK3 AA PGE2 COX2 PGDH Inactive TCF TCF OFFON C”
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets (2007, background): “Altogether, the principal carcinogenetic pathways known to be deregulated in HCC are the inactivation of TP53(6), Wnt/wingless activation mainly through CTNNB1 mutations activating ß-catenin and AXIN1 inactivating mutations(7-9), retinoblastoma inactivation through RB1 and CDKN2A promoter methylatio”
Wnt/β-catenin signaling in cancers and targeted therapies (2021, background): “Axin1 mutations were detected widely in HCC.(156,157) This mutation could phenocopy various tumors in animal models.”
WNT signalling pathways as therapeutic targets in cancer (2012, background): “Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis.”