Molecular pathogenesis of human hepatocellular carcinoma

By Snorri Thorgeirsson, Joe W. Grisham. Nature Genetics, 2002

1,597 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/05bcd2f473706d1eedb7beda9c1cf9f48a48b5b5

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In Cancer Research

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Citations in the corpus

• Therapeutic delivery of miR-26a inhibits cancer cell proliferation and induces tumor-specific apoptosis (2009, neutral): “Hepatocellular carcinoma (HCC) is the third-leading cause of death from cancer and the fifth most common malignancy worldwide (Roberts, 2008; Thorgeirsson and Grisham, 2002).”
• Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. (2006, background): “Hepatocellular carcinoma (HCC) represents an extremely poor prognostic cancer (Thorgeirsson and Grisham, 2002).”
• Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues (2006, neutral): “E-mail: kshimoto@virus.kyoto-u.ac.jp Oncogene (2006) 25, 2537–2545 & 2006 Nature Publishing Group All rights reserved 0950-9232/06 $30.00 www.nature.com/onc O N C O G E N O M IC S (Brechot et al., 2000; Thorgeirsson and Grisham, 2002).”
• Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets (2007, background): “Liver cirrhosis of any origin and dysplastic regenerative nodules have long been considered to be the likely precursors of HCC because of their frequent association with the HCC occurrence(2, 3).”
• Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis (2017, background): “the formation of monoclonal populations of dysplastic hepatocytes in foci and nodules.[46,47] It has been noted that the risk for HCC is greater when the cirrhosis is due to viral hepatitis compared to nonviral causes.”
• CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway (2008, background): “Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide affecting one million individuals annually (Thorgeirsson and Grisham, 2002).”