Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
By Michael Karin, Y. Ben‐Neriah. Annual Review of Immunology, 2000
5,004 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/09abf1e9b4924835c3fcc1bc88bc6ca28edfd7c4
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Citations in the corpus
- DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. (2013, background): “For the activation of NF-jB, IjB is phosphorylated by IjB kinase (IKK) at Ser32 and Ser36 (human IjB), which leads to the ubiquitination and proteasomal degradation of IjB [148].”
- RNA recognition and signal transduction by RIG‐I‐like receptors (2009, background): “The canonical IKK complex, consisting of IKK-a, IKK-b, and the regulatory subunit NF-jB essential modulator (NEMO) (also termed IKK-c), phosphorylates IjB, and subsequent proteasome-dependent degradation of IjB allows functional NF-jB to translocate to the nucleus (73).”
- Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. (2004, unknown): “(De-Introduction shaies, 1999; Karin and Ben-Neriah, 2000; Kondo and Kaelin, 2001; Ohh et al., 2002; Bloom and Pagano, 2003).”
- p38-dependent marking of inflammatory genes for increased NF-κB recruitment (2002, background): “IκBs are regulatory proteins that sequester transcription factors of the NF-κB family in the cytoplas”
- IκBα and p65 Regulate the Cytoplasmic Shuttling of Nuclear Corepressors: Cross-talk between Notch and NFκB Pathways (2003, background): “NF B is a family of transcription factors, including p50, p52, p65, RelB, and c-Rel, that associate as homo- or heterodimers to form the transcriptional regulatory complexes (reviewed in Karin and Ben-Neriah, 2000).”
- Phosphorylation: Implications in Cancer (2017, background): “There are mainly three signalling pathways [56] for its activation, which involve phosphorylation and then proteasomal degradation of the inhibitory factor IκB [57, 58].”
- The IKK NF-κB system: a treasure trove for drug development (2004, background): “Interestingly, NF-κB1 and NF-κB2 are initially made as the larger precursors p105 and p100, respectivel”