Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

By Y. Rubtsov, J. P. Rasmussen, E. Chi, J. Fontenot, L. Castelli, X. Ye, P. Treuting, Lisa Siewe, Axel Roers, W. Henderson and 2 more. Immunity, 2008

1,549 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/09a0d06f9bc1a2f3164a25f044c59d63b651b9c4

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In Immunology

Citations in the corpus

Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “Although it is also expressed by other leukocyte populations, deletion of Il10 selectively in T Reg cells resulted in the development of spontaneous colitis and exaggerated immune responses at other environmental interfaces such as the skin and lung”
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells (2011, background): “Although IL-10 production by T reg cells is not required for the suppression of systemic autoimmunity, it is essential for the control of local immune responses in the lungs and intestinal trac”
T-bet controls regulatory T cell homeostasis and function during type-1 inflammation (2009, background): “For example, IL-10 produced by T reg cells is required for the control of inflammatory responses at mucosal surfaces but is dispensable for the suppression of deleterious immune responses in other tissue”
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses (2010, positive): “Mice Mirn146a / (M.P.B., K.D.T., D.S. Rao, L. Yang, M. Kalwani, Y. Garcia-Flores, M. Luong, A. Devrekanli, J. Xu, G. Sun, J. Tay, P.S. Linsley, and D.B., unpublished data), Foxp3KO (Fontenot et al., 2003), Foxp3YFP-cre (Rubtsov et al., 2008), SOCS1fl (Tanaka et al., 2008), and Stat1 / (Meraz et al.,”
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response (2011, background): “To investigate whether splenic T FR cells stably express Foxp3, we immunized Foxp3-Cr”
Activation of the receptor (Gpr109a) for niacin and the commensal metabolite butyrate suppresses colonic inflammation and carcinogenesis (2014, positive): “IL-10 deficiency leads to spontaneous colitis (Huber et al., 2011; Izcue et al., 2009; Rubtsov et al., 2008).”
Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “Whereas many cell types such as MNP and B cells can produce IL-10 in the intestine (Saraiva and O'Garra, 2010), CD4+ T cells appear to be a key functional source (Roers et al., 2004; Rubtsov et al., 2008).”