Mechanobiology of YAP and TAZ in physiology and disease
By T. Panciera, L. Azzolin, M. Cordenonsi, S. Piccolo. Nature reviews. Molecular cell biology, 2017
1,246 citations recorded by the source corpus.
A growing body of evidence suggests that mechanical signals emanating from the cell's microenvironment are fundamental regulators of cell behaviour. Moreover, at the macroscopic scale, the influence of forces, such as the forces generated by blood flow, muscle contraction, gravity and overall tissue rigidity (for example, inside of a tumour lump), is central to our understanding of physiology and disease pathogenesis. Still, how mechanical cues are sensed and transduced at the molecular level to regulate gene expression has long remained enigmatic. The identification of the transcription factors YAP and TAZ as mechanotransducers started to fill this gap. YAP and TAZ read a broad range of mechanical cues, from shear stress to cell shape and extracellular matrix rigidity, and translate them into cell-specific transcriptional programmes. YAP and TAZ mechanotransduction is critical for driving stem cell behaviour and regeneration, and it sheds new light on the mechanisms by which aberrant cell mechanics is instrumental for the onset of multiple diseases, such as atherosclerosis, fibrosis, pulmonary hypertension, inflammation, muscular dystrophy and cancer.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/df4ea5ff79465549a2af3f12dfc51c955da625c4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Molecular Biology
- Rakesh K. Jain
- Lance L. Munn
- Hadi Tavakoli Nia
- Dai Fukumura
- Triantafyllos Stylianopoulos
- J. Joyce
- Peter Carmeliet
- N. Ferrara
Citations in the corpus
- Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “The extensive role of YAP/TAZ in cell processes elucidates the role of mechanotransduction in development and diseases, such as cancer [108].”
- Physical traits of cancer (2020, background): “YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-bindingmotif) have been identified as potent mechanoresponsive factors (33) that respond to physical cues, such as stretching (22, 34) and cell crowding (34), by translocating from the cytoplasm to the nucleus.”