Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo

By D. Guardavaccaro, Y. Kudo, J. Boulaire, M. Barchi, L. Busino, M. Donzelli, F. Margottin-Goguet, P. Jackson, L. Yamasaki, M. Pagano. 2003

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Ubiquitin signalling in the NF-κB pathway (2005, background): “Genetic deletion of βTrCP1 in mice leads to only modest retardation of IκBα degradation, suggesting that βTrCP1 and βTrCP2 may have redundant function”
Control of the SCFSkp2–Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase (2004, methodology): “Methods Cell culture and biochemistry Cell culture and synchronization of HeLa, Rat-1, 293T and T98G cells were done as describe”
The SCF ubiquitin ligase: insights into a molecular machine (2004, background): “The block on APC/C is removed by yet another activity of SCF β-Trcp — the ubiquitin-mediated degradation of Emi1 (Ref”
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer (2008, background): “β-Trcp1 −/− mice have been shown to have impairment in spermatogenesis and reduced fertility without signs of gross tissue abnormalitie”