Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

By S. Grivennikov, Kepeng Wang, D. Mucida, C. Stewart, B. Schnabl, Dominik Jauch, K. Taniguchi, Guann‐Yi Yu, C. Österreicher, K. Hung and 11 more. Nature, 2012

1,264 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/090cf3638fa160d98c303737eda5cc43c85dda51

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Karin
2. A. Mantovani
3. Guido Kroemer
4. S. Grivennikov
5. L. Zitvogel
6. F. Greten
7. C. Garlanda
8. S. Shalapour

In Oncology

1. M. Karin
2. S. Grivennikov
3. F. Greten
4. A. Mantovani
5. C. Garlanda
6. Guido Kroemer
7. S. Shalapour
8. D. Pardoll

Citations in the corpus

• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Recently, inflammation caused by a barrier defect, which is characteristic for the majority of sporadic CRCs, was shown to play a major role in the initiation and progression of CRC (10, 11).”
• Tumor-associated macrophages: from basic research to clinical application (2017, background): “Recently, the presence of TAM-derived inflammatory cytokines IL-23 and IL-17 has been shown to be closely associated with cancer progression [35].”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “For example, the presence of TAM-derived inflammatory cytokines interleukin (IL)-23 and IL-17 have been shown to trigger tumor-elicited inflammation, which in turn drives tumor growth [20] (Fig.”
• The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide (2013, background): “Intestinal dysbiosis, which constitutes a disequilibrium in the bacterial ecosystem, can lead to overrepresentation of some bacteria able to promote colon carcinogenesis by favoring chronic inflammation or local immunosuppression (2, 3).”
• Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, positive): “Furthermore , elevated expression of IL-17A and IL-23R in stage I and II human CRC correlates with rapid progression to lethal metastatic disease (36).”
• Gut Microbiota Orchestrates Energy Homeostasis during Cold. (2015, positive): “Fresh antibiotics were administered in the drinking water and changed once a week as described (Grivennikov et al., 2012), containing 100μg/ml Neomycin, 50μg/ml Streptomycin, 100U/ml Penicillin, 50μg/ml Vancomycine, 100μg/ml Metronidazole, 1mg/ml Bacitracin, 125μg/ml Ciprofloxacin, 100μg/ml Ceftazid”