Tumor-associated macrophages: from basic research to clinical application

By Li Yang, Yi Zhang. Journal of Hematology & Oncology, 2017

759 citations recorded by the source corpus.

The fact that various immune cells, including macrophages, can be found in tumor tissues has long been known. With the introduction of concept that macrophages differentiate into a classically or alternatively activated phenotype, the role of tumor-associated macrophages (TAMs) is now beginning to be elucidated. TAMs act as “protumoral macrophages,” contributing to disease progression. TAMs can promote initiation and metastasis of tumor cells, inhibit antitumor immune responses mediated by T cells, and stimulate tumor angiogenesis and subsequently tumor progression. As the relationship between TAMs and malignant tumors becomes clearer, TAMs are beginning to be seen as potential biomarkers for diagnosis and prognosis of cancers, as well as therapeutic targets in these cases. In this review, we will discuss the origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/de6f1f2c9baeb4d58c78ffd333a9ac4637d5056c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Paulina Krzyszczyk
2. Andre F. Palmer
3. Yuxin Lin
4. Francois Berthiaume
5. Jianxin Xu
6. R. Schloss
7. Huiyin Lan

In Oncology

1. Yuxin Lin
2. Jianxin Xu
3. Huiyin Lan

Citations in the corpus

• The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes (2018, background): “There also exist cancer-specific macrophages, called tumorassociated macrophages (TAMs), which support tumors by stimulating angiogenesis, aiding in metastasis and inhibiting Tcell anti-tumor responses (Yang and Zhang, 2017).”
• The Tumor Microenvironment Innately Modulates Cancer Progression (2019, background): “Simplistically, Mjs can be polarized into inflammatory M1 (classically activated) or immune-suppressive M2Mjs (alternatively activated) (2).”
• Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “Carlumab CCL2 Monotherapy Solid tumors 1b Antitumor activity [135]”