A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance

By T. Mah, B. Pitts, B. Pellock, G. Walker, P. Stewart, G. O’Toole. Nature, 2003

1,192 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Periodontics

View Paper: https://www.semanticscholar.org/paper/7abfb2aeb04ff244e88b995bda10f4b813d07683

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Kim Lewis
2. J. Ghigo
3. C. Beloin
4. D. Lebeaux
5. Xian-Zhi Li
6. H. Nikaido
7. K. Poole
8. Amy Spoering

In Molecular Biology

1. Kim Lewis
2. D. Lebeaux
3. J. Ghigo
4. C. Beloin
5. R. Vasudevan
6. Amy Spoering
7. N. Kaldalu
8. M. Franklin

In Periodontics

1. R. Vasudevan
2. D. Lebeaux
3. C. Beloin
4. J. Ghigo
5. Amy Spoering
6. P. Stewart
7. N. Kaldalu
8. Iris Keren

Citations in the corpus

• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “aeruginosa mutants, making biofilms more sensitive to tobramycin, and they identified 3 genes or operons: ndvB, PA1875 to PA1877 (PA1875–PA1877), and tssC1 (67).”
• Biofilms: Microbial Cities of Scientific Significance (2014, background): “In addition, scientific investigations and demonstrative studies have confirmed the existence of mechanism within the biofilms that are capable of sequestering the antimicrobial agents and prevent them from reaching their target site [95,96].”
• Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. (2006, background): “Other evidence suggests that biofilm bacteria may have genetic mechanisms, selected for in the biofilm, that provide antimicrobial protection.(29-31) In addition, the biofilm provides a physical barrier that enhances pathogen resistance to host defenses such as opsonization, lysis by complement, and”
• Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix (2009, neutral): “are notoriously difficult to eradicate [2,3].”
• Pseudomonas Aeruginosa: Resistance to the Max (2011, background): “A second gene linked to biofilm-specific resistance to aminoglycosides in some strains only, ndvB, is involved in the synthesis of periplasmic (and intracellular) glucans that bind aminoglycosides (tobramycin), suggestive of a mechanism of resistance whereby aminoglycosides are sequestered and preve”
• Staphylococcus epidermidis – the “accidental” pathogen (2009, neutral): “gov/sites/entrez?db=genomeprj&cmd=Retrieve&dopt=Overview&list_uids=12339"> Pseudomonas aeruginosa alginat”
• Antimicrobial Polymers in Solution and on Surfaces: Overview and Functional Principles (2012, background): “Such biofilms allow microbial cells to survive under harsh conditions and the embedded cells are up to 1,000 times less susceptible to most antibiotics and other biocides [5].”
• Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli (2004, background): “So far, studies aimed at identifying genes responsible for biofilm resistance were limited to the bulk of the population (33), which is fairly susceptible to therapeutic doses of antibiotics or may express resistance genes that act equally well in exponentially growing cells (9, 18).”