Molecular basis of metastasis.

By A. Varki, N. Varki, L. Borsig. New England Journal of Medicine, 2009

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Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation (2011, background): “Metastasis is a complicated process, involving multiple steps and a variety of genes.(16,17) It is becoming evident that a large proportion of long noncoding RNAs that are pervasively transcribed in the genome are highly conserved and, thus, biologically functional, yet their potential role in human”
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip (2010, background): “of clusters of CTCs in the blood of patients with cancer may provide insight into the process of metastasis in human cancer (27).”
Metastasis: from dissemination to organ-specific colonization (2009, background): “General classes of metastasis genes The genes and activities that underlie these general steps of metastasis can be grouped into several classes, which we define as metastasis initiation, metastasis progression and metastasis virulence gene”
Tumor self-seeding by circulating cancer cells (2009, background): “In contrast, metastasis is thought to depend on cancer cell dissemination and adaptation to distant organs (Chiang and Massagué, 2008; Langley and Fidler, 2007; Scheel et al., 2007).”