IRF3 mediates a TLR3/TLR4-specific antiviral gene program.

By S. Doyle, Sagar A. Vaidya, Ryan M. O’Connell, H. Dadgostar, P. Dempsey, Ting-ting Wu, G. Rao, Ren Sun, M. Haberland, R. Modlin and 1 more. Immunity, 2002

945 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/07d4baad7edd675085a49391abb88dc4be255a04

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Citations in the corpus

TLR signaling pathways. (2004, background): “IFN-␤, in turn, activates Stat1, leading to the induction of several IFN-inducible genes [35] [36] [37].”
A Large Fraction of Extragenic RNA Pol II Transcription Sites Overlap Enhancers (2010, background): “We next evaluated if the identified TFBSs are functional. Some of the inducible Pol_II peaks in the region upstream of Ccl5 scored positively for IRF3 (as well as other IRFs) and NF-kB, which are known to coregulate Ccl5 expression”
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF (2003, background): “Thus, TLR3 and TLR4 appear to have evolutionarily diverged from other TLRs to activate gene expression programs and trigger antiviral responses by a mechanism involving the coordinate activation of NF- B and IRF-3 (17).”
Transcriptional regulation via the NF-κB signaling module (2006, background): “IRF-3 activation through phosphorylation by upstream kinases (Fitzgerald et al., 2003; Sharma et al., 2003) occurs in response to the LPS responsetransducing TLR4, but not in response to many other NF-kB-inducing signaling pathways (Doyle et al., 2002).”
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. (2006, methodology): “org Volume 116 Number 4 April 2006 993 LPS activates NF-kB and IRF3 via MyD88-dependent and -independent signaling, respectively (21, 30).”
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β (2008, background): “17 ), whereas TLR3 signals from a distinct endosomal compartment, where it activates IRF3 through a TRIF-dependent pathwa”
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction (2003, background): “TLR3 signaling activates IFN-β expression to a greater extent than genes induced by NF-κ”