CpG motifs in bacterial DNA and their immune effects.

By A. Krieg. Annual Review of Immunology, 2002

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View Paper: https://www.semanticscholar.org/paper/07ae288eb9f22295fcab8ef95269f04c22313e39

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In Microbiology

Citations in the corpus

Poultry coccidiosis: recent advancements in control measures and vaccine development (2006, background): “184 Krieg AM, Yi AK, Matson S et al. CpG motifs in bacterial DNA trigger direct Bcell activation.”
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Finally, viral or bacterial DNA contains multiple unmethylated CpG motifs that can bind and activate TLR9 (Ref”
MyD88: a central player in innate immune signaling (2014, background): “It has been appreciated for quite some time that different classes of CpG motifs (A or B) favor type I IFN or pro-inflammatory cytokine production, respectively [55].”
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. (2005, background): “While originally thought of as a receptor that recognized bacterial DNA, TLR9 has been demonstrated to directly mediate recognition of unmethylated CpG DNA sequences regardless of origin (29, 30).”
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007, background): “CpG ODN is a potent generator of both type I/II interferons and IL-12 (Krieg, 2002) and data not shown), therefore, we examined the effects of CD8 T cell priming with IL-12 and IFNγ directly.”
Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. (2011, background): “responsible for host immune responses to invading pathogens.(32,33) Interestingly, syn-”
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. (2004, background): “Local aqueous siRNA activity has been observed for several tissues (5,8,9), but is lacking in tumors (10), and systemic exposure can induce non-specific responses, as found for CpG DNA oligonucleotides (10, 11 ).”
Therapeutic potential of Toll-like receptor 9 activation (2006, background): “TLR9-stimulated B cells and pDC show increased expression of co-stimulatory molecules , resistance to apoptosis, upregulation of the chemokine (C-C motif) receptor CCR7 , and secretion of T H 1-promoting chemokines and cytokines such as monocyte inflammatory protein-1 (MIP1), IFNγ-inducible 10-kDa”
Pathogen recognition and innate immunity. (2006, neutral): “Bacterial DNA Bacterial genomic DNA is also an immunostimulant and is recognized by TLR9 (Hemmi et al., 2000; Krieg, 2002).”