ATP-sensitive potassium channelopathies: focus on insulin secretion.

By Frances M. Ashcroft. Journal of Clinical Investigation, 2005

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Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators (2009, background): “In addition, it has been suggested that ATP acts as an intracellular or extracellular signaling molecule in cellular processes, such as insulin secretion (1), neurotransmission (2), cell motility (3), and organ development (4).”
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians (2011, background): “This variant or others influencing KCNK16 may result in the defective regulation of potassium channel activity that contributes to the etiology of T2”
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome (2009, background): “The SUR subunits belong to the ATP-binding cassette (ABC) transporter family (Aguilar-Bryan et al., 1995) and function as a regulatory subunit, endowing the Kir6.x channel with sensitivity to inhibition by sulfonylureas such as glyburide and glipizide (Ashcroft, 2005).”
Inwardly rectifying potassium channels: their structure, function, and physiological roles. (2010, background): “The amount of the reduction in ATP sensitivity of the channels correlates with the severity of the phenotype (16).”