Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

By Y. Cho, Chien-Hsiun Chen, Cheng Hu, J. Long, R. Ong, X. Sim, F. Takeuchi, Ying Wu, M. Go, Toshimasa Yamauchi and 56 more. Nature Genetics, 2011

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How researchers see this paper

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Five years of GWAS discovery. (2012, neutral): “Please see the ref [40] for a comprehensive overview of this method.”
The genetic architecture of type 2 diabetes (2016, background): “We then assigned names to the resulting state definitions: (1) H3K4me3, H3K27ac (active promoter); (2) H3K4me3, H3K27ac, H3K4me1 (active enhancer 1); (3) H3K27ac, H3K4me1 (active enhancer 2); (4) H3K4me1 (weak enhancer); (5) H3K27me3, H3K4me3, H3K4me1 (poised promoter); (6) H3K27me3 (repressed); (7)”
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes (2012, neutral): “Although the genetic contribution to T2D is well recognized, the current set of 56 established susceptibility loci, identified primarily through large-scale genome-wide association studies (GWAS) 2–11 , captures at best 10% of familial aggregation of the disease.”