Glutathione Pathways in the Brain

By R. Dringen, J. Hirrlinger. Biological chemistry, 2003

606 citations recorded by the source corpus.

Subfields: Biochemistry, Nutrition and Dietetics, Oncology

View Paper: https://www.semanticscholar.org/paper/071a2f7d3a693e3dce1e06f67c9bde7c196dc630

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Lambros
2. A. Massie
3. S. Gandhi
4. M. Duchen
5. A. Abramov
6. Sylvia B. Smith
7. V. Ganapathy
8. Jieun E. Kim

In Nutrition and Dietetics

1. M. Duchen
2. A. Abramov
3. A. Methner

In Oncology

1. M. Duchen
2. A. Abramov

Citations in the corpus

• Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation (2007, background): “GSH provides one of the major antioxidant mechanisms in the CNS and is oxidized in response to oxidative stress, and GSH depletion leads to CNS pathology (Dringen and Hirrlinger, 2003).”
• Mechanism of Oxidative Stress in Neurodegeneration (2012, background): “GSH peroxidase and GSH reductase can act enzymatically to remove H2O2 and maintain GSH in a reduced state [102].”
• The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “GSH can be regenerated from glutathione disulfide by the reaction with glutathione reductase that transfers electrons from NADPH to glutathione disulfide [54, 55].”
• Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, background): “Astrocytes have a substantially higher GSH content than neurons and appear responsible for the maintenance of GSH levels in neurons by releasing GSH which is broken down by an ectoenzyme into a dipeptide that can then be used by neurons to maintain their own levels of GSH (Keelan et al., 2001; Dring”
• The Cystine/Glutamate Antiporter System xc − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities (2013, positive): “GSH synthesized from cyst(e)ine taken up by system xc - is, in part, exported from cells and thereby can regulate extracellular cysteine levels by disulfide exchange with cystine, leading to the formation of GSH-cysteinyl disulfide and cysteine or by catabolism of GSH through GGT and dipeptidases (5”