Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells.

By D. Richard, E. Berra, J. Pouysségur. Journal of Biological Chemistry, 2000

670 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/068450fa2af30dcc37519ae5ff9ab14f1806de30

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In Cancer Research

1. Max Costa
2. Richard J. Johnson
3. Yan Huang
4. Ion S. Jovin
5. P. Comoglio
6. V. Haase
7. J. Ziello
8. Qingdong Ke

In Genetics

1. Max Costa
2. Kai-Uwe Eckardt
3. Richard J. Johnson
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In Molecular Biology

1. A. V. van Oosterom
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3. Max Costa
4. Richard J. Johnson
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6. E. D. de Bruijn
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8. P. Comoglio

Citations in the corpus

• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “ROS are known to activate and stabilize hypoxia-inducible factor 1 (HIF1 ) (248).”
• Hypoxia-Inducible Factor-1 (HIF-1) (2006, background): “…HIF-1 Stiehl et al., 2002 Insulin-like growth factor (IGF)-1, IGF-2 ROS Increased HIF-1 Feldser et al., 1999 Fetal calf serum ROS Increased HIF-1 Richard et al., 2000 Angiotensin II (Ang II) Thrombin, Platelet-derived growth factor (PDGF) ROS Increased HIF-1 Gorlach et al., 2001 Nitric oxide…”
• Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. (2003, methodology): “An breast epithelium; MLP-29, murine hepatocyte precursors) or inactive, mutant form of HIF-1 (Richard et al., 2000) was used tumors (A549, human lung carcinoma; SK-OV-3, human ovarian as a negative control.”
• Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. (2007, background): “In addition to hypoxic stabilization of HIF-1α, several factors relevant to renal fibrogenesis, including nitric oxide, TNF-α (8, 9), angiotensin II (10), IL-1 (11), insulin and insulin-like growth factors (11–13), have been shown to induce nonhypoxic HIF-1α stabilization.”
• Vascular Endothelial Growth Factor and Angiogenesis (2004, background): “…have postulated that HIF-1 itself, as an iron-containing protein, can perform this function, whereas others have suggested that a NAPDH-linked oxidase is involved (Forsythe et al., 1996; Ryan et al., 1998; Srinivas et al., 1998; Dachs and Tozer, 2000; Richard et al., 2000; Tsuzuki et al., 2000).”
• Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its Potential for Therapeutic Intervention in Malignancy and Ischemia (2007, background): “Thrombin and other growth factors increase angiogenesis via HIF-1α protein agonist mechanisms [14,33].”
• Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, neutral): “stabilization [ 238 , 239 ].”