3D tomography reveals connections between the phagophore and endoplasmic reticulum

By Päivi Ylä-Anttila, H. Vihinen, Eija Jokitalo, E. Eskelinen. Autophagy, 2009

656 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0654663ca42fe2842af9865843aeccafc48411a3

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Citations in the corpus

An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “The source of membrane that makes up the phagophore is highly debated, but various studies have implicated the plasma membrane (120, 121), ER (41, 155), Golgi complex (134), and mitochondria (36) as possible sources (107, 145).”
Autophagy: assays and artifacts (2010, background): “TEM has recently been used to great effect in combination with tomographical approaches to identify regions of the endoplasmic reticulum as the likely origin of autophagosomes in mammalian cells [6,7].”
Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “Although an equivalent structure seems to be absent from mammalian cells, a special subdomain in the endoplasmic reticulum (ER) termed the “omegasome” has been suggested as a putative origin of autophagosomes (3, 33, 115).”
LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis (2010, background): “Autophagy is initiated by the formation of a cup-shaped membrane that has been recently suggested to originate from the endoplasmic reticulum (Hayashi-Nishino et al, 2009; Yla-Anttila et al, 2009).”
The origin of the autophagosomal membrane (2010, background): “In yeast, the Atg effector-proteins recruited by PtdIns(3)P are Atg18 and Atg21; the mammalian homologues of Atg18 are WIPI2 and WIPI1–4 (WD-40 repeat-containing protein that interacts with PtdIns)31,32.”
Mitochondria supply membranes for autophagosome biogenesis during starvation (2010, background): “Electron microscopy (EM) tomography has revealed close apposition of ER and phagophore membranes, most apparent when phagophore maturation is blocked (Hayashi-Nishino et al., 2009; Ylä-Anttila et al., 2009).”
Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy and mitochondrial fusion dynamics (2015, background): “One is through autophagic digestion of membrane-bound organelles (i.e., the ER) or LDs (Axe et al., 2008; Hayashi-Nishino et al., 2009; Kristensen et al., 2008; Singh et al., 2009a; Ylä-Anttila et al., 2009).”
Autophagy in immunity and inflammation (2011, background): “The ER cisternae often associate with developing autophagosomes, and electron tomography analysis has demonstrated direct connections between the ER and autophagosomal membranes 10, 11 .”
The regulation of autophagy – unanswered questions (2011, methodology): “In the second model, a subdomain of the ER is initially used as a cradle for the formation of the phagophore that expands between ER domains to which it is physically linked (Hayashi-Nishino et al., 2009; Ylä-Anttila et al., 2009).”