Molecular physiology of cardiac repolarization.
By J. Nerbonne, R. Kass. Physiological Reviews, 2005
1,064 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/062d1497eccd845deab11049132677a097dcceda
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In Cardiology and Cardiovascular Medicine
In Cellular and Molecular Neuroscience
In Molecular Biology
Citations in the corpus
- Hyperpolarization-activated cation channels: from genes to function. (2009, neutral): “Inwardly rectifying K currents that activate over a similar voltage range as Ih are also blocked by this cation (99, 288, 289).”
- Rotors and the Dynamics of Cardiac Fibrillation (2013, background): “Although relevant, the studies in the mouse did not reveal the role of the 2 main repolarizing K currents in the human ventricle, that is, the fast and the slow delayed rectifier K currents, namely, I Kr and I Ks .(106) These currents do not contribute in a meaningful way to the short APD in the mou”
- Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. (2007, background): “The -subunit KChIP2, which is critical for the formation of functional Ito channels (219), was found to be unaltered at the mRNA level by heart failure in two studies (8, 373) and downregulated in one (265); however, in all three studies KChIP2 protein expression was unaltered.”
- Role of the Autonomic Nervous System in Atrial Fibrillation: Pathophysiology and Therapy (2014, background): “4 subunits.(54) I KACh activation produces an outward K current that flows throughout the depolarized phases of the cardiac action potential, resulting in substantial reduction in action potential duration (APD).”
- hERG K(+) channels: structure, function, and clinical significance. (2012, background): “, midmyocardial cells (Mcells) have a reduced IKs repolarizing conductance and enhanced depolarizing conductances, both of which contribute to a longer action potential duration (24, 443).”