Hyperpolarization-activated cation channels: from genes to function.

By M. Biel, C. Wahl-Schott, S. Michalakis, X. Zong. Physiological Reviews, 2009

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Mechanisms underlying spontaneous patterned activity in developing neural circuits (2009, background): “Pacemakers in the adult nervous system are typically depolarized by either a hyperpolarization-activated cation conductanc”
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate cellular excitability and synaptic signal integration (Biel et al., 2009) and subunits HCN1–HCN4 are differentially expressed in various brain regions (L€orincz et al., 2002; Notomi and Shigemoto, 2004).”
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms (2012, positive): “The depolarization inactivates Ih until the train of action potentials is followed by a hyperpolarizing overshoot, which opens HCN channels and the cycle can repeat (Biel et al., 2009).”
Macrophages Facilitate Electrical Conduction in the Heart (2017, positive): “We found that HCN4-expressing cardiomyocytes (Biel et al., 2009), particularly in the lower nodal or AV bundle, frequently intersperse with macrophages (Figure 1B).”