Rotors and the Dynamics of Cardiac Fibrillation
By S. Pandit, J. Jalife. Circulation Research, 2013
398 citations recorded by the source corpus.
The objective of this article is to present a broad review of the role of cardiac electric rotors and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset, we present a brief historical overview regarding reentry and then discuss the basic concepts and terminologies pertaining to rotors and their initiation. Thereafter, the intrinsic properties of rotors and spiral waves, including phase singularities, wavefront curvature, and dominant frequency maps, are discussed. The implications of rotor dynamics for the spatiotemporal organization of fibrillation, independent of the species being studied, are described next. The knowledge gained regarding the role of cardiac structure in the initiation or maintenance of rotors and the ionic bases of spiral waves in the past 2 decades, as well as the significance for drug therapy, is reviewed subsequently. We conclude by examining recent evidence suggesting that rotors are critical in sustaining both atrial and ventricular fibrillation in the human heart and its implications for treatment with radiofrequency ablation.
Subfields: Cardiology and Cardiovascular Medicine
View Paper: https://www.semanticscholar.org/paper/9fad56ceaffe244178253b3d9a9c54e9f048c8ca
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation (2017, background): “The transition likely reflects progressive structural and electrophysiological remodeling in both atria, making the sources of the arrhythmia more stable by fundamental mechanisms that have been incompletely explored.(153,154,155,156)”
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. (2016, neutral): “On the other side are those who adhere to the theory that fibrillation is a consequence of the continued activity of a few vortices (rotors) that spin at high frequencies, generating ‘fibrillatory conduction’.(236,237) In either case, arrhythmia maintenance is favoured by abbreviated APD/refractory ”
- Role of the Autonomic Nervous System in Atrial Fibrillation: Pathophysiology and Therapy (2014, background): “The precise details of mechanisms maintaining re-entry (Figures 5D), such as the structure and number of circuits, role of rotors, remain controversial.(74) However, shortened refractoriness promotes functional re-entry in all conceptual models.”