Early life antibiotic‐driven changes in microbiota enhance susceptibility to allergic asthma

By Shannon L. Russell, Matthew J. Gold, Martin Hartmann, B. Willing, L. Thorson, M. Wlodarska, Navkiran Gill, Marie-Renée Blanchet, W. Mohn, K. McNagny and 1 more. EMBO Reports, 2012

840 citations recorded by the source corpus.

Subfields: Dermatology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/05f8e8c69476ff084bbb606d3a7324ba86af106b

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Citations in the corpus

Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, result): “Concordant with these findings, studies in mice have shown that neonatal (from pre-birth) but not adult exposure to antibiotics resulted in exacerbated asthma following intranasal challenge with ovalbumin [90].”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “As discussed below for metabolic diseases, antibiotic-induced modification of the early-life microbiota has been shown to increase the risk of allergic asthma in laboratory animals (317).”
The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks (2020, background): “Consistently, lung exposure to commensal bacteria reduces Th2-associated cytokine production after an allergen challenge and induces regulatory cells early in life (Russell et al., 2012; Gollwitzer et al., 2014).”
How informative is the mouse for human gut microbiota research? (2015, background): “The number of associations between gut microbiota composition and function and host diseases is increasing, with such diseases including obesity, IBD, diabetes and allergic diseases, such as asthma (Russell et al., 2012) and atopy (Lee et al.”
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, positive): “A protective role of commensals and potentially their metabolites from asthma has been suggested (Russell et al., 2012).”
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “IgE antibodies play a critical role in allergies, asthma, and immunity to parasites (120), and studies of human infants and animal models support a role for mucosal microbiota in asth ma and atopic disease development (121-123).”
Interaction between microbiota and immunity in health and disease (2020, background): “However, the 'window of opportunity' thus created, may also render infants more susceptible to environmental incursions to the microbiota, with potentially long-lasting harmful impacts on immunity.(21) The immaturity of the immune system in newborns and infants is highlighted by an increased suscept”
Commensal bacteria protect against food allergen sensitization (2014, neutral): “1E), consistent with another recent report (13).”