Highly Conserved Protective Epitopes on Influenza B Viruses

By C. Dreyfus, N. S. Laursen, Ted H. J. Kwaks, D. Zuijdgeest, R. Khayat, D. Ekiert, J. H. Lee, Zoltan Metlagel, M. Bujny, M. Jongeneelen and 16 more. 2012

870 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

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Citations in the corpus

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes (2016, background): “The cross-group neutral- izing antibodies 39.29, FI6v3, and CR9114 (Corti et al., 2011; Dreyfus et al., 2012; Nakamura et al., 2013), as well as the group 1-neutralizing antibodies F10 andCR6261 (Ekiert et al., 2009; Sui (A) HA is shown in surface representation and residues that are contacted by ME”
Quantifying B cells capable of producing broadly neutralizing antibodies against influenza serves as a metric to guide the development of a universal influenza vaccine (2016, neutral): “, 2013) CR9114 HV1-69 14% HV SHM 14aa CDR H3 (Dreyfus et al., 2012) A”
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses (2020, background): “In contrast, the immunologically subdominant stem region of HA is highly conserved among and across subtypes and targeted by a number of bNAbs capable of crossreacting with multiple viral subtypes [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] .”
Conserved Neutralizing Epitope at Globular Head of Hemagglutinin in H3N2 Influenza Viruses (2014, methodology): “Preparation of MAbs.”
Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies (2013, background): “Antibodies with reactivity toward the stalk domain of influenza B virus HA have also been described (9).”
A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV (2020, background): “(27), herpesvirus (28), cytomegalovirus (29), alphavirus (30), and dengue virus (31).”
Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach (2019, background): “domain (MAbs CR9114 and 5A7) (29, 31) and against the head domain (MAbs CR8033”
Accurate Measurement of the Effects of All Amino-Acid Mutations on Influenza Hemagglutinin (2016, neutral): “Shown are footprints of F10, CR6261, FI6v3, and CR9114 (Sui et al., 2009; Ekiert et al, 2009; Corti et al, 2011; Dreyfus et al, 2012).”
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages (2018, neutral): “Monoclonal antibodies have been 77 identified that bind conserved HA stem epitopes and possess broad neutralizing activity across 78 diverse HA subtypes within an influenza A group, and some that have cross-group neutralizing 79 activity (6-16).”