Autophagy in infection, inflammation, and immunity

By V. Deretic, T. Saitoh, Shizuo Akira. Nature reviews. Immunology, 2013

1,829 citations recorded by the source corpus.

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/05de2388b0e68a030566d21e02b2e78d1c893f8b

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Citations in the corpus

To be or not to be? How selective autophagy and cell death govern cell fate. (2014, positive): “…we have focused on the selective removal of damaged organelles, we note that insights can be gleaned from examination of the process of xenophagy, the selective removal of infectious intracellular organisms by autophagic processes (Deretic et al., 2013), and this may inform our model further.”
Molecular definitions of autophagy and related processes (2017, neutral): “…as novel therapies for multiple human disorders and pathophysiological conditions, including neurodegenerative (Menzies et al , 2015), infectious (Deretic et al , 2013), autoimmune (Deretic et al , 2013; Zhong et al , 2016), cardiovascular (Shirakabe et al , 2016), rheumatic (Rockel & Kapoor,…”
Autophagy during viral infection — a double-edged sword (2018, background): “As clearance of cytoplasmic components is a major function of autophagy, the innate immune system activates autophagy to degrade and dispose of invading viruses 11 .”
Macrophage defense mechanisms against intracellular bacteria (2015, background): “tuberculosis and drive phagosome maturation toward phagolysosomes and auto-phagolysosomes (54, 55).”
Mechanisms of Selective Autophagy (2016, neutral): “[17,18]).”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Second, these receptors can induce dynamic cellular processes that function as part of the immune response (Figure 1) (6, 7, 15).”
Autophagy in malignant transformation and cancer progression (2015, positive): “Autophagy mediates potent anti-inflammatory effects (Deretic et al , 2013).”
Autophagy and autophagy-related proteins in cancer (2020, background): “Among mammal ATG proteins, Beclin-1, ATG5, ATG7, ATG12, ATG16L1 and LC3B are the most studied with respect to inflammation [207], and defects in autophagy are linked to many inflammatory diseases [208, 209] and cancer [210].”