Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells

By N. Bernasconi, E. Traggiai, A. Lanzavecchia. Science, 2002

1,417 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/05b734c5e03bd838ee914efe31c39e7f533efd9e

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In Immunology

1. S. Ghosh
2. M. Hayden
3. R. Medzhitov
4. Bali Pulendran
5. Rafi Ahmed
6. A. West
7. Shizuo Akira
8. A. Iwasaki

Citations in the corpus

• The regulation of IgA class switching (2008, result): “Similar to B-1 and marginal-zone B cells, human IgM memory and transitional B cells exhibit robust antibody responses to microbial TLR and BCR ligand”
• Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “In addition, TLRs might continuously trigger long-lived memory B cells to maintain ‘‘serological memory’’ (Bernasconi et al., 2002). restricted, their antibody may constitute a dominant fraction of serum IgM and up to half of IgA molecules in the gut and is often reactive to host molecules.”
• Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function (2005, result): “Efficient self presentation by such DCs could restimulate memory T cells, similar to the proposal made for the maintenance of B cell memor”
• Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients (2020, background): “When combined with the parallel formation of re-activatable memory B cells (43), many of which will be tissue-resident (25), the host has excellent mecha-”
• Pattern recognition receptors and control of adaptive immunity (2009, background): “As mentioned above, TLRs can also directly activate memory B cells for antibody production (17).”
• Toll-like receptor control of the adaptive immune responses (2004, background): “Human memory B cells produced antibodies in response to CpG stimulation independently of antigen-specific cognate T cell hel”