Lipid Rafts As a Membrane-Organizing Principle

By D. Lingwood, K. Simons. Science, 2010

4,224 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0576f71d2e566028fef991d2e799bb22448b7702

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Citations in the corpus

Membrane organization and lipid rafts. (2011, background): “…as dynamic nanoscale sterol, sphingolipid-enriched, ordered assemblies of specific proteins, in which the metastable resting state can be activated to coalesce by specific lipid–lipid, protein–lipid, and protein–protein interactions (Hancock 2006; Lingwood and Simons 2010; Simons and Gerl 2010).”
Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “PM lipid domains are indispensable for the assembly of signalosomes and subsequently play a key role in their internalization [64,65].”
Computational Modeling of Realistic Cell Membranes (2019, background): “In fact, the heterogeneous nature of the cell membrane is underlying the raft concept, 4,5 which, in its current form, states that speci ﬁ c lipids together with proteins can cluster into nanodomains.”
Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis (2011, background): “This complex arrangement of proteins and lipids in the plasma membrane is believed to be critical to various physiological processe”
Lipidomics: coming to grips with lipid diversity (2010, background): “The controversies due to crude biochemical methods, such as detergent insolubility and cholesterol depletion, are being overcome by the influx of new advanced spectroscopic, imaging and lipidomics technologie”
High-resolution atomic force microscopy and spectroscopy of native membrane proteins (2011, background): “Due to lipid microdomains that may exclude or concentrate certain membrane proteins [288], molecular crowding [289–291], organization in supramolecular complexes and anchoring to the cytoskeleton [292], the diffusion of membrane proteins is often hindered.”
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease (2012, positive): “In support of this view, we note that the membrane thickness of LRs is greater than that of the surrounding bilayer (Risselada and Marrink, 2008; Lingwood and Simons, 2010), and that the thickness of model membranes affects the cleavage speciﬁcity of g -secretase as well as the relative amounts of…”
Revitalizing membrane rafts: new tools and insights (2010, methodology): “Hence, we are left with a description of plasma membranes that could correspond to three states, of which two are seen in living cell”