Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues
By Doralicia Casares, P. Escribá, C. A. Rosselló. International Journal of Molecular Sciences, 2019
669 citations recorded by the source corpus.
Biological membranes are key elements for the maintenance of cell architecture and physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the plasma membrane is a scaffold and player in cell-to-cell communication and the initiation of intracellular signals among other functions. Critical to this function is the plasma membrane compartmentalization in lipid microdomains that control the localization and productive interactions of proteins involved in cell signal propagation. In addition, cells are divided into compartments limited by other membranes whose integrity and homeostasis are finely controlled, and which determine the identity and function of the different organelles. Here, we review current knowledge on membrane lipid composition in the plasma membrane and endomembrane compartments, emphasizing its role in sustaining organelle structure and function. The correct composition and structure of cell membranes define key pathophysiological aspects of cells. Therefore, we explore the therapeutic potential of manipulating membrane lipid composition with approaches like membrane lipid therapy, aiming to normalize cell functions through the modification of membrane lipid bilayers.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a05a72e3a3ccb5c015b434e07a8673a5df687bc3
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Citations in the corpus
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research (2020, background): “Many of these effects are consistent with a nonspecific action of PFAS on the cellular lipid membrane (Spector and Yorek 1985; Bourre et al. 1989; Dodes Traian et al. 2012; Casares et al. 2019).”