Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
By R. Pappu, Susan R. Schwab, I. Cornelissen, J. P. Pereira, J. Regard, Ying Xu, E. Camerer, Yaowu Zheng, Yong Huang, J. Cyster and 1 more. Science, 2007
935 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/056931ae910eef2bbcae4003a504f078f08c369b
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In Cell Biology
In Molecular Biology
- Sarah Spiegel
- Susan R. Schwab
- S. Milstien
- J. Cyster
- Ulrich H. von Andrian
- K. Takabe
- S. Paugh
- V. Brinkmann
Citations in the corpus
- Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M (2011, background): “Plasma S1P, which is derived from several cellular sources (11, 12), is associated with HDL (∼65%) and albumin (∼35%) (3, 5).”
- “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “, 2007), appear to be a major contributor to the storage and supply of plasma S1P (Hänel et al., 2007; Pappu et al., 2007).”
- Follicular shuttling of marginal zone B cells facilitates antigen transport (2008, background): “S1P is abundant in blood and is thought to be present in much smaller amounts in the follicles and T zones of lymphoid tissue”
- Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “The concentration of S1P in lymph, in the nanomolar range, is approximately one sixth the concentration in plasm”
- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis (2010, background): “and the local production of S1P by lymphatic endothelial cells expressing the lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1”
- Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “The S1P gradient between LNs and lymph fluid is maintained by the S1P-degrading enzyme S1P lyase (Schwab et al., 2005), which is abundant in most tissues and cell types except in platelets and erythrocytes (Pappu et al., 2007).”