Development of monocytes, macrophages and dendritic cells

By F. Geissmann, M. Manz, Steffen Jung, M. Sieweke, Miriam Merad, Klaus Ley. Science, 2010

3,175 citations recorded by the source corpus.

Development of Myeloid Immune Cells As leukocytes develop to maturity, they proceed through an array of phenotypically distinct intermediates. For T and B lymphocyte populations, the different developmental stages, anatomical locations, and cell signals required for progression are well established. However, until recently, much less has been known about how development proceeds in the myeloid lineage, which includes monocytes, macrophages, and dendritic cells. Geissmann et al. (p. 656) review our current understanding of myeloid lineage development and describe the developmental pathways and cues that drive differentiation. Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/05387262a67d3c47ee3a65320f63c02503f59f13

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In Immunology

1. A. Mantovani
2. A. Sica
3. S. Gordon
4. P. Murray
5. P. Allavena
6. TA Wynn
7. P. Italiani
8. D. Boraschi

Citations in the corpus

• Monocyte recruitment during infection and inflammation (2011, background): “Macrophage and DC progenitors (MDPs) give rise to monocyte progenitors and also to common DC progenitors (CDPs”
• Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “Thus, pDCs may develop in a less linear fashion than suggested (51) and originate from a continuum of progenitors with DC and/or lymphoid potential.”
• The role of immune dysfunction in the pathophysiology of autism (2011, positive): “The elimination of functional MHCI results in atypical synaptic plasticity in animal models, further illustrating the essential role for MHCI in synapse remodeling (Goddard et al., 2007).”
• Structure-function of the immune system in the spleen (2019, background): “Monocytes Monocytes are present in the BM, blood, and spleen and can differentiate into multiple specialized myeloid subsets (56).”