Integrin-associated protein (CD47) and its ligands.

By E. Brown, W. Frazier. Trends in Cell Biology, 2001

885 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/05017c5d76aadccd5b75f690fdea54474efdaf72

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Irving L. Weissman
2. Francis G. Spinale

In Immunology

1. Irving L. Weissman
2. R. Majeti
3. W. Pang
4. P. Henson
5. M. Chao
6. J. Seita
7. M. Clarke
8. Siddhartha Jaiswal

In Immunology and Allergy

1. Irving L. Weissman
2. Francis G. Spinale

Citations in the corpus

• Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. (2005, positive): “CD47 (integrin-associated protein, IAP), is widely distributed on cells and binds to a number of proteins (Brown and Frazier, 2001; Cant and Ullrich, 2001), including SIRPα, a heavily glycosylated transmembrane protein with an immunoreceptor tyrosine-based inhibition motif (ITIM) domain.”
• CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells (2009, background): “CD47 is a widely expressed transmembrane protein (Brown and Frazier, 2001).”
• A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation (2003, background): “…to promote cell– cell adhesion through its interactions with fibrillar proteins such as TSP-1 and cell surface proteins on adjacent cells (Jiang et al., 1999; Babic et al., 2000) and has been demonstrated to have a role in integrin-independent signaling events (Brown and Frazier, 2001).”
• Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. (2007, background): “TSP signaling likely involves mitogen-activated protein kinase and ultimately the formation of AP-1 transcriptional complexes (48, 97, 137).”
• Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response (2013, background): “CD47 is highly expressed on cancer cells as compared with normal cells (5, 6) and interacts with the ligand signal regulatory protein α (SIRP-α) on macrophages (7).”
• Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma (2010, neutral): “expressed transmembrane protein (Brown and Frazier, 2001).”
• CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. (2009, positive): “CD47 is an immunoglobulin-like protein that is known to interact functionally with integrins (Brown and Frazier, 2001) and thrombspondin-1 (Gao et al., 1996; Liu et al., 2001).”
• The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors (2012, background): “CD47 is a widely expressed transmembrane protein with numerous functions (6).”