Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells1

By C. Mottet, H. Uhlig, F. Powrie. Journal of Immunology, 2003

1,040 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/04c40aed7a61db2be5aa1084a566c2e079e30c44

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In Immunology

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In Oncology

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Citations in the corpus

• TLR Signaling in the Gut in Health and Disease1 (2005, background): “Patients homozygous for the 3020insC frameshift mutation in the Nod2 gene demonstrate defective release of IL-10 from PBMC after stimulation with TLR2 ligands (87).”
• Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo (2012, result): “have been shown to be protective in some studies (Mottet et al., 2003; Huter et al., 2008; Haribhai et al., 2011) although others have reported less efficacy (Hill et al.”
• A guide to histomorphological evaluation of intestinal inflammation in mouse models. (2014, background): “Intraperitoneal transfer of 4×105 CD4+CD45RBhigh T cells into syngeneic Rag1-ko mice induced intestinal inflammation within 4-8 weeks [15].”
• Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. (2006, background): “Furthermore, transfer of CD25 CD4 T cells into mice with an experimental immune-mediated colitis leads to resolution of colitis.(29) Therefore, it has been postulated that antibody to CTLA4 might deplete Treg cells and thus induce autoimmunity.”
• Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1 (2005, background): “Recently, transfer of CD4 CD25 cells has been shown to cure established colitis (18, 34) and early onset diabetes (31), if administered in sufficient numbers or activation status.”
• The Glucose Transporter Glut1 is Selectively Essential for CD4 T Cell Activation and Effector Function (2014, positive): “The requirement of Teff for Glut1 to induce inflammatory bowel disease (IBD) was first tested using an adoptive transfer model (Mottet et al., 2003) in which sorted naive control andCD4CreGlut1fl/fl T cells were transferred into immunodeficient Rag1 / recipients.”
• A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “Furthermore, adoptive transfer of CD4CD25 Treg cures established CD4CD45RB transfer colitis [185].”
• Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells (2004, background): “Conversion of an established immune pathology by Tregs has only been described recently (49).”