Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.
By Kimberly E. Beck, J. Blansfield, K. Tran, A. Feldman, M. Hughes, R. Royal, U. Kammula, S. Topalian, R. Sherry, D. Kleiner and 5 more. Journal of Clinical Oncology, 2006
805 citations recorded by the source corpus.
Subfields: Gastroenterology, Genetics, Oncology
View Paper: https://www.semanticscholar.org/paper/4792dfea69df84c362f0e38926f006038962772d
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Citations in the corpus
- Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. (2016, background): “…be disturbed in cancer bearers, for instance during chemotherapy-induced mucositis (Zitvogel et al., 2015), IEC-killing during CTLA4 blockade (Beck et al., 2006; Berman et al., 2010; Vétizou et al., 2015) or IEC damage and bacterial translocation during CTX therapy, exacerbated in the…”
- Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis (2007, background): “The most frequent major organ toxicities in patients with melanoma were enteritis (particularly colitis with diarrhea) and hypophysitis that occurred in 21% and 5% of patients, respectively.(13,17) Dermatitis and sporadic cases of arthritis, hepatitis, nephritis, iritis, and vitiligo were also seen.”
- Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors. (2016, neutral): “The gastrointestinal tract is a privileged environment for the induction of Foxp3+ Treg cells in response to oral antigens, which play a pivotal role in the maintenance of immune tolerance (Belkaid and Hand, 2014).”