Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

By John T. Chang, V. Palanivel, I. Kinjyo, F. Schambach, A. Intlekofer, A. Banerjee, Sarah A. Longworth, Kristine E Vinup, Paulus Mrass, J. Oliaro and 5 more. Science, 2007

910 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/045e511e6dc49cc35288eeb381be924573bd6684

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “Asymmetric cell division after T cell activation controls downstream fate (32).”
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “Applying emerging new observations such as possible fate-determining signals imprinted by early inflammatory cytokines or the asymmetric separation of daughter T cells (Chang et al., 2007) and other signals should empower and enhance vaccine design.”
Germinal-center organization and cellular dynamics. (2007, background): “In one study, cells expressing high amounts of Ig mRNA were found at the base of the light zone; however, these cells were relatively infrequent and expressed large amounts of cytoplasmic Ig protein, suggesting that they might have been antibodysecreting plasma cells (Close et al., 1990).”
Mechanisms of asymmetric stem cell division. (2008, background): “A beautiful recent study has turned this into the best understood asymmetric cell division in vertebrates that shows a striking conservation of the machinery used in Drosophila neuroblasts (Chang et al., 2007).”
The PI3K pathway in human disease (2017, positive): “This was shown ﬁrst in CD8 + T cells, where the ﬁrst division results in one CD8-high daughter cell with high potential to proliferate and differentiate into cytotoxic effectors and one CD8-low daughter cell destined to seed the memory CD8 T cell pool (Chang et al., 2007).”
Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. (2010, background): “previous reports that Blimp-1 expression is upregulated by increased IL-2 signals ( Calame, 2008; Gong and Malek, 2007; Malek, 2008), and that Blimp-1 drives terminal-effector differentiation (Rutishauser et al., 2009), CD25hi cells that are capable”
Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8+ T Cell Memory Development (2011, background): “It is also possible that mitochondria segregate unequally as T cells asymmetrically divide so that terminally differentiated Teff cells acquire fewer mitochondria (Chang et al., 2007).”