Oxidative mechanism of arsenic toxicity and carcinogenesis

By Honglian Shi, Xianglin Shi, K. Liu. Molecular and Cellular Biochemistry, 2004

696 citations recorded by the source corpus.

Subfields: Environmental Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0450d50a6adca9c8ed6344761a9c548ef3560975

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In Environmental Chemistry

1. S. Flora
2. S. Chatterjee
3. R. Moogouei
4. I. Sharma
5. D. Gupta
6. A. Mitra

In Molecular Biology

1. K. Jomová
2. S. Flora
3. M. Valko
4. A. Hartwig
5. Zhushan Fu
6. D. Gupta
7. Shuhua Xi
8. D. Beyersmann

Citations in the corpus

• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “ROS-induced alteration of gene expression can occur through a modulation of a host of signaling pathways including cAMP-mediated cascades, calcium-calmodulin pathways, and intracellular signal transducers such as nitric oxide (Shi, Shi, and Liu 2004; Bertin and Averbeck 2006).”
• Arsenic induced oxidative stress in plants (2012, background): “Dimethylarsinic acid (DMA) causes iron-dependent oxidative stress which is based on iron released from ferritin whereas, DNA damage take place by reactive oxygen species which are generated directly from DMA3+ (Shi et al. 2004).”
• Arsenic: toxicity, oxidative stress and human disease (2011, background): “Inorganic arsenic tends to be farmore toxic than organic arsenic (Shi et al., 2004; Valko et al., 2005).”
• Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “In addition to oxidative DNA damage, metals cause changes in DNA methylation and histone modifications, leading to epigenetic silencing or reactivation of gene expression [107–109].”
• Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “Both superoxide (O2‚´) and the subsequently generated H2O2 and ‚OH interact with biological macromolecules, leading to DNA damage, lipid peroxidation and alteration of the levels of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) [86].”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Additionally, several specific types of environmental stress can lead to the production of ROS, including heat stress (297), herbicide/insecticide contamination (3), environmental toxins (240), and ultraviolet light exposure (235).”
• The effects of heavy metals on human metabolism (2019, background): “species (ROS) (Shi et al. 2004), altered DNA methylation (Zhao et al.”
• Arsenic exposure and toxicology: a historical perspective. (2011, background): “Reactive species are formed in vitro and in vivo in the presence of arsenic and include superoxide anion, hydroxyl radical, hydrogen peroxide, reactive nitrogen species, and arsenic-centered and arsenic peroxyl radicals (Kitchin 2001; Shi et al., 2004).”
• Oxidative Stress and Antioxidant Defense (2012, background): “57 – 59 Arsenic (III) compounds can inhibit antioxidant enzymes, especially the GSH-dependent enzymes, such as glutathione-S -transferases (GSTs), glutathione peroxidase (GSH-Px), and GSH reductase, via binding to their sulfhydryl ( – SH) groups.”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “2 Genetic and related effects Arsenicals do not react directly with DNA, but cells treated with low concentrations of trivalent arsenicals show increased oxidative DNA damage (Wang et al., 2002; Schwerdtle et al., 2003; Shi et al., 2004; Ding et al., 2005; Wang et al., 2007a).”
• Arsenic Accumulation in Rice and Probable Mitigation Approaches: A Review (2017, background): “Iron (Fe) is an essential element in plants required for various metabolic activities like, photosynthesis, respiration, DNA synthesis, and co-factors for several enzymes.”
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms (2008, background): “Furthermore, interactions of arsenic with cellular protection mechanisms against ROS, in particular a decrease in glutathione levels and the disturbance of DNA repair systems, contribute to increased levels of oxidative damage in cells (reviewed by Shi et al. 2004 ).”
• Chelation in Metal Intoxication (2010, background): “[91] provided evidence that arsenic generates free radicals that leads to cellular damage and death through the activation of oxidative sensitive signaling pathways.”