Chelation in Metal Intoxication
By S. Flora, V. Pachauri. International Journal of Environmental Research and Public Health, 2010
851 citations recorded by the source corpus.
Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. 2,3-Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, however its serious side effects have led researchers to develop less toxic analogues. Hydrophilic chelators like meso-2,3-dimercaptosuccinic acid effectively promote renal metal excretion, but their ability to access intracellular metals is weak. Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently. In this review we provide an update of the existing chelating agents and the various strategies available for the treatment of heavy metals and metalloid intoxications.
Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/9915fd1cc4b736b85eabd63bc11ff508b2df49d7
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Citations in the corpus
- Cadmium toxicity and treatment: An update (2017, background): “Optimal effects of chelating agent therapy may be achieved when combination of DMSA and MiADMSA is administered (77).”
- The Effects of Cadmium Toxicity (2020, background): “DMSA analogs, such as the esters MmDMSA (monomethyl DMSA), MiADMSA (monoisoamyl DMSA), and MchDMSA (monocyclo hexyl DMSA), are more effective and safe antidotes for heavy metal poisoning compared to DMSA [49].”