Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms.

By G. Longo, Wanfen Xiong, T. Greiner, Yong Zhao, N. Fiotti, B. Baxter. Journal of Clinical Investigation, 2002

1,145 citations recorded by the source corpus.

Subfields: Cancer Research, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/044e63dd94d20d56d2569bb0881325205ebbb789

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Gillian Murphy
2. R. Khalil
3. Hideaki Nagase
4. Xi Wang
5. R. Visse
6. A. Newby
7. C. Malemud
8. M. Xue

In Pulmonary and Respiratory Medicine

1. Gillian Murphy
2. Hideaki Nagase

In Surgery

1. Gillian Murphy
2. Hideaki Nagase
3. A. Newby

Citations in the corpus

• Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. (2008, background): “Also, both MMP-2 and -9 are necessary to induce experimental AAA formation in mice [60].”
• Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. (2005, background): “This principle was clearly demonstrated in the study by Baxter and colleagues (166), where knockout of either MMP-2 or -9 was sufficient to prevent calcium-induced aortic aneurysm formation in mice.”
• Matrix metalloproteinases. (2010, background): “Other studies have shown positive association between MT1-MMP (MMP-14) and ischemia-reperfusion [188], the importance of MMP-2 and MMP-9 for the development of abdominal aortic aneurysm [189] and the protective roles MMP-3 and MMP-9 have on atherosclerotic plaque stability [190].”
• Structure and function of matrix metalloproteinases and TIMPs. (2006, positive): “A critical role of MMP-2 and MMP-9 has been also shown for the development of abdominal aortic aneurysm using MMP gene deletion mice [12].”
• Progress in matrix metalloproteinase research. (2008, methodology): “A critical role of MMP-2 and MMP-9 has been also shown for the development of abdominal aortic aneurysm using MMP gene deletion mice (Longo et al., 2002).”
• Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. (2018, background): “MMP-2 and MMP-9 appear to be necessary to induce AAA formation in mice (Longo et al., 2002), and targeted gene disruption of MMP-9 in mice suppresses the development of AAA (Pyo et al.”
• Matrix metalloproteinases (MMPs) in health and disease: an overview. (2006, background): “In cardiovascular pathology, aberrant MMP catalytic activity has also been linked to atherosclerotic plaque formation and plaque instability (29), vascular smooth muscle cell migration and restenosis (30), development of aortic aneurysm (31) and progressive heart failure in animal models (32) and hu”