Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

By M. Hamilton, D. G. Hamilton, T. Zderic. Diabetes, 2007

1,728 citations recorded by the source corpus.

Subfields: Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/0440ebbd4cc1aba0fdd53ac19bdd13673cfb9f7e

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Citations in the corpus

Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. (2011, background): “may result in reduced lipoprotein lipase activity and clearance of plasma triglycerides, reduced clearance of an oral glucose load from plasma, and less glucose-stimulated insulin secretion.(21) The”
Physical activity for health: What kind? How much? How intense? On top of what? (2011, background): “Physiologic studies of light activities, such as standing, report not only substantial muscular activity but also healthful metabolic change, thereby providing support for the evidence that light activities are beneficial with respect to sedentary activity (24, 25, 51, 52, 91, 100).”
Physiological and health implications of a sedentary lifestyle. (2010, background): “Low levels of LPL are associated with increased circulating triglyceride levels, decreased HDL cholesterol, and an increased risk of cardiovascular disease (Hamilton et al. 2007).”
Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses (2012, background): “Estimating the caloric expenditure of such changes would be informative; the increased substrate utilization that is required to meet differences in energy demands when transitioning from sitting to standing may be an important mechanism (37,38).”
The role of exercise and PGC1α in inflammation and chronic disease (2008, background): “Furthermore, if the age of onset of a particular disease or the extent of disease is dose responsive with respect to the concentrations of systemic inflammatory molecules, then sedentary behaviour coupled with obesity would be expected to bring about disease earlier and/or in a more severe for”
So depression is an inflammatory disease, but where does the inflammation come from? (2013, neutral): “lipoprotein lipase [102]; responsible for controlling process associate d with metabolic risk factors.”
Breaks in Sedentary Time (2008, background): “However, there is emerging evidence that another set of behaviors, involving prolonged periods of inactivity and absence of whole body movement, is distinctly related to risk of chronic disease independent of physical activity (4).”