Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses
By David W. Dunstan, B. Kingwell, R. Larsen, G. Healy, Ester Cerin, M. Hamilton, J. Shaw, D. Bertovic, P. Zimmet, J. Salmon and 1 more. Diabetes Care, 2012
1,168 citations recorded by the source corpus.
OBJECTIVE Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS Overweight/obese adults (n = 19), aged 45–65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95% CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS The glucose iAUC (mmol/L) ⋅ h after both activity-break conditions was reduced (light: 5.2 [4.1–6.6]; moderate: 4.9 [3.8–6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5–8.7]). Insulin iAUC (pmol/L) ⋅ h was also reduced with both activity-break conditions (light: 633.6 [552.4–727.1]; moderate: 637.6 [555.5–731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0–950.9]). CONCLUSIONS Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
Subfields: Complementary and alternative medicine, Physiology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/59d440ab2be9746417ce00ff099229203b4a3bd2
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Citations in the corpus
- The Theory of Planned Behavior as a model for understanding sedentary behavior (2015, positive): “In a recent intervention study, Dunstan et al. (2012) showed that interrupting sitting time with 2-min bouts of light or moderate intensity walking every 20 min lowered postprandial glucose and insulin levels in overweight/obese adults.”
- Personalized Nutrition by Prediction of Glycemic Responses. (2015, background): “Factors that may affect interpersonal differences in PPGRs include genetics (Carpenter et al., 2015), lifestyle (Dunstan et al., 2012), insulin sensitivity (Himsworth, 1934), and exocrine pancreatic and glucose transporters activity levels (Gibbs et al., 1995).”
- Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association (2016, background): “Increasing nonexer-cise activity, even in brief (3 2 15 min) bouts, is effective in acutely reducing postprandial hyperglycemia and improving glycemic control in those with prediabetes and type 1 and type 2 diabetes, most prominently after meals (41,43 – 46, 75,”
- Sedentary time in adults and the association with diabetes, cardiovascular disease and death: systematic review and meta-analysis (2012, background): “Our findings, combined with the preliminary experimental findings by Dunstan et al [48], suggest that reducing sedentary time may have a significant role in diabetes prevention.”
- Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis (2018, background): “in the evening following the main meal of the day [95], may exacerbate the repetitive cardiovascular effects of postprandial glucose and lipid excursions following this meal, especially if TV viewing is predominantly accumulated in prolonged bouts of sitting [96, 97].”