LncRNADisease: a database for long-non-coding RNA-associated diseases

By Geng Chen, Ziyun Wang, Dongqing Wang, Chengxiang Qiu, Mingxi Liu, Xing Chen, Qipeng Zhang, Guiying Yan, Qinghua Cui. Nucleic Acids Res., 2012

917 citations recorded by the source corpus.

In this article, we describe a long-non-coding RNA (lncRNA) and disease association database (LncRNADisease), which is publicly accessible at http://cmbi.bjmu.edu.cn/lncrnadisease. In recent years, a large number of lncRNAs have been identified and increasing evidence shows that lncRNAs play critical roles in various biological processes. Therefore, the dysfunctions of lncRNAs are associated with a wide range of diseases. It thus becomes important to understand lncRNAs’ roles in diseases and to identify candidate lncRNAs for disease diagnosis, treatment and prognosis. For this purpose, a high-quality lncRNA–disease association database would be extremely beneficial. Here, we describe the LncRNADisease database that collected and curated approximately 480 entries of experimentally supported lncRNA–disease associations, including 166 diseases. LncRNADisease also curated 478 entries of lncRNA interacting partners at various molecular levels, including protein, RNA, miRNA and DNA. Moreover, we annotated lncRNA–disease associations with genomic information, sequences, references and species. We normalized the disease name and the type of lncRNA dysfunction and provided a detailed description for each entry. Finally, we developed a bioinformatic method to predict novel lncRNA–disease associations and integrated the method and the predicted associated diseases of 1564 human lncRNAs into the database.

Subfields: Cancer Research, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/03a37cdb44e914a0889c2a9e8a46197497cc23f9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

  1. Xing Chen
  2. Zhuhong You
  3. Chenggang Clarence Yan
  4. Xu Zhang
  5. Qinghua Cui
  6. Zhou Huang
  7. Zhen Yang
  8. Zhenyu Bao

In Epidemiology

  1. Jo Vandesompele

In Molecular Biology

  1. Xing Chen
  2. Zhuhong You
  3. Chenggang Clarence Yan
  4. Xu Zhang
  5. Qinghua Cui
  6. Zhou Huang
  7. Zhen Yang
  8. Zhenyu Bao

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