TANRIC: An interactive open platform to explore the function of lncRNAs in cancer

By Jun Li, Leng Han, Paul L. Roebuck, L. Diao, Lingxiang Liu, Yuan Yuan, John N. Weinstein, Han Liang. Cancer Research, 2015

472 citations recorded by the source corpus.

Long noncoding RNAs (lncRNAs) have emerged as essential players in cancer biology. Using recent large-scale RNA-seq datasets, especially those from The Cancer Genome Atlas (TCGA), we have developed “The Atlas of Noncoding RNAs in Cancer” (TANRIC, http://bioinformatics.mdanderson.org/main/TANRIC:Overview), a user-friendly, open-access web resource for interactive exploration of lncRNAs in cancer. It characterizes the expression profiles of lncRNAs in large patient cohorts of 20 cancer types, including TCGA and independent data sets (>8,000 samples overall). TANRIC enables researchers to rapidly and intuitively analyze lncRNAs of interest (annotated lncRNAs or any user-defined ones) in the context of clinical and other molecular data, both within and across tumor types. Using TANRIC, we have identified a large number of lncRNAs with potential biomedical significance, many of which show strong correlations with established therapeutic targets and biomarkers across tumor types or with drug sensitivity across cell lines. TANRIC represents a valuable tool for investigating the function and clinical relevance of lncRNAs in cancer, greatly facilitating lncRNA-related biological discoveries and clinical applications.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/73daf5feb858460ddfc16b14457f653482001704

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs (2016, unknown): “Although a platform has already been developed to fill this gap (Li et al. 2015), to help the scientific community study lncRNAs OncoLnc incorporates analyses and data for recent miRBase definitions: http://www.mirbase.org/.”
Comprehensive Genomic Characterization of Long Non-Coding RNAs across Human Cancers (2015, background): “In addition to the fact that they are highly deregulated in tumors (Akrami et al., 2013; Calin et al., 2007; Du et al., 2013; Iyer et al., 2015; Kim et al., 2014; Li et al., 2015; Ling et al., 2013; Prensner et al., 2011; Trimarchi et al., 2014; Xing et al., 2014), lncRNAs have been found to act as ”
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses (2017, background): “Multiple public resources such as cBioPortal [25,26], miRGator v 3.0 [29], TANRIC [30], and ISOexpresso [31] aid in the comprehensive analysis of transcriptomic TCGA data.”